You seem to have a fairly high end machine so I will give you the plugin set I use:
Video: GSDX (SSSE3 version) - Be sure to configure it and set it to run in DirectX 10 mode (since your video card DOES support that)
Audio: SPU-X - I Find this to be the most complete audio plugin thus far and the time stretching effect used when the emulator does slow down sounds a LOT better than the choppiness other audio plugins create
Input: Whatever you prefer depending on the controller you have.
Cd/DVD Rom: Make sure this is set to read ISOs. Do not run the game through your discs because it's horribly slow. Dump your discs to ISOs first and then run that.
Keep the rest of the plugins at their default.
MISC: You may or may not want to set the default cycle rate to 2x under speed hacks (also make sure you have enabled multi-threaded support too). This is a personal preference though because it WILL cause some FMVs to be choppy but it's made up for the performance increase you get. For example, for me in FFXII, there were times when the framerate would drop to 45-50 but with the speed hack on, I could keep it at a full 60FPS.
Video: GSDX (SSSE3 version) - Be sure to configure it and set it to run in DirectX 10 mode (since your video card DOES support that)
Audio: SPU-X - I Find this to be the most complete audio plugin thus far and the time stretching effect used when the emulator does slow down sounds a LOT better than the choppiness other audio plugins create
Input: Whatever you prefer depending on the controller you have.
Cd/DVD Rom: Make sure this is set to read ISOs. Do not run the game through your discs because it's horribly slow. Dump your discs to ISOs first and then run that.
Keep the rest of the plugins at their default.
MISC: You may or may not want to set the default cycle rate to 2x under speed hacks (also make sure you have enabled multi-threaded support too). This is a personal preference though because it WILL cause some FMVs to be choppy but it's made up for the performance increase you get. For example, for me in FFXII, there were times when the framerate would drop to 45-50 but with the speed hack on, I could keep it at a full 60FPS.