I have a problem with a game called Thousand Arms; The intro plays correctly, but when I hit start, the screen goes blank. The music continues, but nothing is on the screen.
I use Pete's OpenGL2 plugin, and his IOCTL CDROM plugin.
You can make an ISO with several programs, such as Alcohol 120% (use the PlayStation preset in the ISO wizard), CloneCD (use the Game preset), or ISO Producer. Also, your card can handle the very high X and Y resolution settings, if you set it to that your games will look nicer.