[Jax]

i cant save the game using ePSXe 1.40, than i try to press F4 but it crash, any1 can help me

 

[Betamax]

Its a stab in the dark but try pressing f4 and then f5 to see if that works.

 

[Adair]

Do you mean your PC crashes from windows, or the game just freezes? If it freezes go with what Betamax posted. If it crashes then you may have to use savestates instead.
F1= save to active slot
F2= increase slot number (1-5)
F3= load from active slot