What Lex said. Development for No$GBA is halted at the moment. The author still hasn't announced anything about it being stopped, so for No$, that's all you'll get. No$zoomer does give certain patches to fix issues on some games, but that's about it.
Desmume needs a(n even more) powerful hardware, but if you have a good rig, it can take more out of it (for certain games) than No$. It is also the only real legal alternative for those who didn't get No$GBA 2.6a and hence can't use No$Zoomer to its full extent.
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