What games are you trying to run? What are your exact settings for the plugins you are using? If all else fails I have heard some guys have had the same problem of epsxe not responding, and they completely unistaled and deleted epsxe from the registary and started over. That seemed to fix there problems. I my self had never had that much trouble. Also what are your comp specs?
Here is what my settings are for GT2 and 1.
My Coputer specs.
1.3GHz Athlon,
200MHz System Bus,
56k modem,
128mb DDR RAM/PC1600,
40GB 7200 rpm Hard Drive,
32MB Nvidia TNT2 Pro,
Creative Labs Sound Blaster PCI 128,
12x DVD Drive,
8x4x32 CD-RW Drive,
Plugin: Pete's DX6 D3D Driver 1.1.53
Author: Pete Bernert
GFX card: NVIDIA RIVA TNT2/TNT2 Pro
Resolution/Color:
- 800x600 Fullscreen - [32 Bit]
Textures:
- R8G8A8A8
- Filtering: 2
- Caching: 1
Framerate:
- FPS limit: on
- Frame skipping: off
- FPS limit: Auto
Compatibility:
- Offscreen drawing: 4
- Framebuffer texture: 2
- Alpha multipass: on
- Mask bit: on
- Advanced blending: hardware
Misc:
- Scanlines: off [0]
- Unfiltered FB: off
- Dithering: off
- Full vram: off
- Game fixes: off [00000000]
Iori's Direct sound driver 1.4
null driver (because I use iso's)
Hope this helps