CD-Rom. I have read stuff about work arounds via ISO, but... I was hope there would be a less bull**** way to do it. I am also running ePSXe 1.7.0, latest plugins and the best settings.
I'm running a C2D [email protected] 3.00 ghz
2 gig of Corsair Dominator memory @ 1066mhz
nvidia eVGA mobo 680i SLi
nvidia eVGA vid card 7950gt ko
WD Sata II 250gb HD @ 7200 RPM
I cannot remember the manufacturer of my DVD drive, but its pretty recent and spec'd well.