There are many things that can affect, and posting your current plugin set and configs would help. Wich program did you use to make the ISO, and how do you load it to epsxe? What happens if you load the original disc?
Megaman X5, as every 2D game, works better with peops GPU plugin. What about remaking the ISO, did you do it? Wich program are you using to make your images?
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