Major MGS problem

I have played disc 1 right through and changed to disc 2. Unfortunately the sound no longer works. Then when i try to go down the large 45deg platform lift, a cut scene starts then the whole thing locks. I can still hit esc to drop back to the desktop though.

I have tried the disc in another PC - same effect. I tried running it as an iso - same effect. It works on a real PSX though

This is a UK pal disc

Any ideas ?

ePSXe 1.4
SCPH1001.BIN
Petes OGL 1.52
Petes DSound 1.11
Petes CDR 1.6

Athlon 900
128mb
Windows Me
Plextor x40 SCSI CDROM
Nvidia TNT2
Onboard VIA AC'97 Audio