PCSX2 has more compatibility and has more accuracy of emulation.
Well...wanting to play a game available for both platforms then yeah, there is a difference. If you pick a game and it's only available on GC/Wii (or Vice Versa) then comparing the two emulators is moot. Like I said...Enjoy them both.Of course it makes a difference. What is the point of playing a game that is barely emulated with errors everywhere?