For one, mic support will be even more iffy than it is already. The game will only register some stuttering noise, that might or might not be enough.
Also, you'll obviously won't be able to do time actions as well if you only see one frame in ten.
Lastly, a high frameskip might interfere with saving, increasing the chance of savegame corruption.
BTW, could you name the thing you cannot do on No$?