ok first off, at least learn the ficticious character's names before you call them hot.
Yuna = "FF X girl"
Aya Brea = "that one chick from Parasite Eve"
furthermore, I think this might be in the lead now for most repeated topic on the forums, I swear this must be at least the 3rd time in the last 2 or 3 months I have seen this topic posted.
finally, here are my picks. also since nearly every single anime has had a game made after it at some point, Ill also list ppl from animes that I know have been made into games.
Garnet / Dagger (FFIX)
Selphie (FFVIII)
Aya (Parasite Eve)
85% of all girls in all fighting games (can't over look some of those)
Feena and her sister Leen (Grandia)
Rei Ayanami (Neon Genesis Evangelion)
Shampoo, Akane, Nabiki, Kasumi, Ukyo (Ranma 1/2)
All love hina girls (Love hina)
Lina Inverse (Slayers)
Ayeka (Tenchi (would mention Sakuya, but she wasn't in the game))
Thats all I can think of off the the top of my head, if I think of more, I will post them.