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Which CDROM plugin are you using? Try switching between different ones... I've gotten that error message before, but it was caused by a badly scratched CD.

Since you said that you see the error no matter what game you use, I tend to think it's either a badly configured CDROM plugin, or the DVD/CD drive settings are incorrect.

Also, make sure that the selected CDROM drive letter in the plugin configuration window is consistent between the ePSXe config window, and the plugin's config window.
 
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