This happens every time I try to run any game (including ones I've tested on a machine that I have ePSXe working on).
I'm running Windows 7 64bit (I would've assumed incompatibility issues, but apparently other people have it running on W7-64 just fine and I tried many solutions to that.) I've already searched a lot of the threads and how-tos, and I found nothing that worked for me yet. I tried turning of DEP, and that didn't work either. And yes, I have the latest video and audio drivers installed.
Toshiba Satellite A305-6898
2.0GHz Intel Duo Core
ATI Mobile Radeon 3450 - 256mb
As for plug-ins, I've tried multiple different ones, but by default I'd use Eternal's SPU audio plugin and either PeOP's or built-in plug-ins.
Also, this problem happens for PSXeven as well, so it's not as simple as just using a different emulator.