A thorough description would help. What are you trying to configure and how? Why can't you do it?
First, you need a bios file. You have to dump it yourself from your console. Google will help you on finding info about this. Next, you need the plugins. Download them and unzip them in your plugins folder. The dll files must be directly on the plugins folder, not on a subfolder for themselves. Once you have everything on place, start epsxe up, and go to the "configure" menu. Choose your bios file, and then configure the gpu, spu, and cdrom plugins. To make it simple, d/l peops gpu plugins, or pete's plugins if you have a nice ati or nvidia card (pete's ogl 2 if you have an nvidia of the fx line or later, or an r300 or later radeon). Configure them with the nice preset, and let's see if that works. Later we can get in the deeps of perfect settings .