Don't enable Anti-Aliasing or V-sync as those options tend to cause a significant amount of slowdown, it shouldn't matter if Anisotropic Filtering is enabled since this option doesn't seem to have much of an impact on performance. 1024 x 768 or 1280 x 1024 resolution is probably the lowest and highest you should set the screen resolution at. Setting the screen resolution any higher might cause slowdown in some games. Enable EFB to GL texture in the options, EFB to Ram is quite a bit slower.
I recommend using the DirectX 9 Video Plugin since it runs a bit faster than the OpenGL plugin for some games.
I recommend using the DirectX 9 Video Plugin since it runs a bit faster than the OpenGL plugin for some games.