The gpu plugins I have tried it with are Pete's D3D, Pete's OpenGL and Pete's Software plugin and It worked with all of them. I didn't use any special configurations. The sound plugin I use is Iroi's. I don't think I tried it with any other ones. Maybe there is a CD-Rom problem? When you start it up does the cd-rom drive do ANYTHING? If not, then you haven't configured the cdrom plugin right. I use Pete's CDR plugin. For some reason I have problems using the internal CDR plugin. Do you have any problems running other games with your current config? Maybe thats the problem you are having.