I think that maybe you should turn the FPS Limit to the preset NTSC limit instead of 60. I think that there's a diff. of about .4 FPS that used to make the speech sound weird when I used to play Brave Fencer Musashi. Other than that, I'd say that maybe the effects used in the burning and mist are a bit heavy on frame buffer access, which is the Achilles heel of most any last-gen console emulators.