This is very rare but can happen.Y...
But now I've noticed one other problem (using epsxe 1.7) there is no music(maybe all sound) when I continue the game. That is, when I press Esc to do something and then press run->continue to keep playing. Any ideas for that one?
Even as at Savestates this can happen while ESC-Continue.
As this is made in an unfavorable Moment , it can be that the some Buffers are saved/stopped as they incompletely filled or something.
This can have strange effects like missing or scrambled Sound
You can try an actual version of ePXe or another Soundplugin.
even if it now sounds confusing in this context,
Try to make a SaveState before escape