theres a way to do it
i used to play die hard trilogy using my mouse in the second "film"
go to the control pad config, a look wheres digital only and put digital/ mouse (F5)
it worked for me
or just press F5 during the game
yes and no...technically it's enabled, but many of those games don't have a crosshair so you don't know where you're shooting....I hope in future releases a crosshair will be optionally available....would be so much nicer...(the nes emu loopynes has it too, so you can play duckhunt with mouse).