What game(s) are you trying? Have you tried running one from an ISO? Are they NTSC or PAL? I am guessing this is a CD-ROM plugin issue. Try using PEOPS CDR plugin for PAL or NTSC games (turn on subchannel reading for PAL), using the IOCTL (WNT/W2K) plugin for any non-protected games, or install an ASPI layer (google for Force ASPI) and use the ASPI plugin. If you are using the ASPI plugin and do not have an ASPI layer installed, that would most likely be the problem.