Also as a test try removing all your plugins from epsxe temporarily to see if that gets it working again. If so restore the plugins 1 by one until you find the file that's causing the crash (eg// having 3dfx plugins installed when you have no 3dfx card can cause all sorts of fun )
1. Goto start-> run type 'regedit' (no quotes)
2. Scroll down to you find [hkey_current_user]\software\epsxecutor and delete it.
3. Scroll down to [hkey_current_user]\software\vision thing and delete that key.