Full speed for Pokemon Colosseum? Probably not, however I guess you may achieve at least half the speed I get, compared to my configuration below.
For me, the game runs fullspeed most of the time outside battles (30/30 FPS at 60Hz), and slower during battles (the slowest moment is when there are a lot of menues, for example when you choose the moves to use). Not to mention the random problem causing the emulator to forget to play some sounds...
For me, the game runs fullspeed most of the time outside battles (30/30 FPS at 60Hz), and slower during battles (the slowest moment is when there are a lot of menues, for example when you choose the moves to use). Not to mention the random problem causing the emulator to forget to play some sounds...